Alterations in nitric oxide/cyclic-GMP pathway in nondiabetic siblings of patients with type 2 diabetes.

@article{Piatti2000AlterationsIN,
  title={Alterations in nitric oxide/cyclic-GMP pathway in nondiabetic siblings of patients with type 2 diabetes.},
  author={Piermarco Piatti and Lucilla Domenica Monti and Ivana Zavaroni and Gianpietro Valsecchi and C Van Phan and Sabrina M R J Costa and M. P{\'e}rez-D{\'i}az Conti and Emilia Paola Sandoli and Bruno Sebastiano Solerte and Guido Pozza and Antonio E Pontiroli and Gerald Reaven},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2000},
  volume={85 7},
  pages={2416-20}
}
In this study, we have compared resistance to insulin-mediated glucose disposal and plasma concentrations of nitric oxide (NO) and cyclic-GMP in healthy volunteers with (n = 35) or without (n = 27) at least one sibling and one parent with type 2 diabetes. The 62 volunteers were further divided into groups of those with normal glucose tolerance or impaired glucose tolerance. Insulin-mediated glucose disposal was quantified by determining the insulin sensitivity index (ISI) in response to a low… CONTINUE READING
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