Alterations in neocortical expression of nicotinic acetylcholine receptor mRNAs following unilateral lesions of the rat nucleus basalis magnocellularis

@article{Miyai2005AlterationsIN,
  title={Alterations in neocortical expression of nicotinic acetylcholine receptor mRNAs following unilateral lesions of the rat nucleus basalis magnocellularis},
  author={I. Miyai and S. Ueno and S. Yorifuji and H. Fujimura and S. Tarui},
  journal={Journal of Neural Transmission / General Section JNT},
  year={2005},
  volume={82},
  pages={79-91}
}
  • I. Miyai, S. Ueno, +2 authors S. Tarui
  • Published 2005
  • Biology, Medicine
  • Journal of Neural Transmission / General Section JNT
    • We investigated the effect of a unilateral lesion of the nucleus basalis magnocellularis (nbm) on the expression of nicotinic acetylcholine receptors (nAChRs) in the rat cerebral cortex. Cortical nAChR concentration as determined by [3H]nicotine binding was unaffected by the nbm lesion. Expression levels of nAChR subunit mRNAs were measured using cDNA clones coding for the receptor subunits, alpha-3, alpha-4, and beta-2. At 1 week postlesion, expression levels of alpha-4, and beta-2 were… CONTINUE READING
    View on Springer
    ncbi.nlm.nih.gov
    3 Citations
    3 Citations
    Citation Type

    Citation Type

    Change of central cholinergic receptors following lesions of nucleus basalis magnocellularis in rats: search for an imaging index suitable for the early detection of Alzheimer's disease.
    • 15
    The α3 and α4 nicotinic acetylcholine receptor (nAChR) subunits in the brainstem medulla of sudden infant death syndrome (SIDS)
    • 4
    Impaired spatial working memory and altered choline acetyltransferase (CHAT) immunoreactivity and nicotinic receptor binding in rats exposed to intermittent hypoxia during sleep
    • 75

    References

    SHOWING 1-10 OF 73 REFERENCES
    Effects of Nucleus Basalis Lesions on the Muscarinic and Nicotinic Modulation of [3H] Acetylcholine Release in the Rat Cerebral Cortex
    • 71
    Functional expression of a new pharmacological subtype of brain nicotinic acetylcholine receptor.
    • 306
    Behavioral and neurochemical effects following neurotoxic lesions of a major cholinergic input to the cerebral cortex in the rat
    • 366
    Scopolamine induces up-regulation of nicotinic receptors in intact brain but not in nucleus basalis lesioned rats
    • 14
    Presynaptic Nicotinic Cholinergic Receptors Labeled by [3H]Acetylcholine on Catecholamine and Serotonin Axons in Brain
    • 246
    Long-term neuropathological and neurochemical effects of nucleus basalis lesions in the rat.
    • 165
    Neocortical cholinergic innervation: A description of extrinsic and intrinsic components in the rat
    • 116
    Choline Acetyltransferase Activity in the Rat Brain Cortex Homogenate, Synaptosomes, and Capillaries After Lesioning the Nucleus Basalis Magnocellularis
    • 19
    Spread of acetylcholine sensitivity in the neocortex following lesion of the nucleus basalis
    • 42
    Distribution of alpha2, alpha3, alpha4, and beta2 neuronal nicotinic receptor subunit mRNAs in the central nervous system: A hybridization histochemical study in the rat
    • 1,031