Alterations in mucosal immunity identified in the colon of patients with irritable bowel syndrome.

@article{Aerssens2008AlterationsIM,
  title={Alterations in mucosal immunity identified in the colon of patients with irritable bowel syndrome.},
  author={Jeroen Aerssens and Michael Camilleri and Willem Talloen and Leen Thielemans and Hinrich W. H. G{\"o}hlmann and Ilse van den Wyngaert and Theo Thielemans and Ronald de Hoogt and Christopher N. Andrews and Adil E Bharucha and Paula J. Carlson and Irene A Busciglio and Duane D. Burton and Thomas C. Smyrk and Raul A Urrutia and B. Coulie},
  journal={Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association},
  year={2008},
  volume={6 2},
  pages={194-205}
}
BACKGROUND & AIMS Irritable bowel syndrome (IBS) has been associated with mucosal dysfunction, mild inflammation, and altered colonic bacteria. We used microarray expression profiling of sigmoid colon mucosa to assess whether there are stably expressed sets of genes that suggest there are objective molecular biomarkers associated with IBS. METHODS Gene expression profiling was performed using Human Genome U133 Plus 2.0 (Affymetrix) GeneChips with RNA from sigmoid colon mucosal biopsy… CONTINUE READING

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