Alterations in mossy fiber physiology and GAP-43 expression and function in transgenic mice overexpressing HuD.

@article{Tanner2008AlterationsIM,
  title={Alterations in mossy fiber physiology and GAP-43 expression and function in transgenic mice overexpressing HuD.},
  author={Daniel C. Tanner and Shenfeng Qiu and Federico Bolognani and L Donald L Partridge and Edwin J. Weeber and Nora I. Perrone-Bizzozero},
  journal={Hippocampus},
  year={2008},
  volume={18 8},
  pages={814-23}
}
HuD is a neuronal RNA-binding protein associated with the stabilization of mRNAs for GAP-43 and other neuronal proteins that are important for nervous system development and learning and memory mechanisms. To better understand the function of this protein, we generated transgenic mice expressing human HuD (HuD-Tg) in adult forebrain neurons. We have previously shown that expression of HuD in adult dentate granule cells results in an abnormal accumulation of GAP-43 mRNA via posttranscriptional… CONTINUE READING