Alterations in microglial phenotype and hippocampal neuronal function in transgenic mice with astrocyte-targeted production of interleukin-10.

@article{Almolda2015AlterationsIM,
  title={Alterations in microglial phenotype and hippocampal neuronal function in transgenic mice with astrocyte-targeted production of interleukin-10.},
  author={Beatriz Almolda and Carmen de Labra and Iliana Barrera and Agn{\`e}s Gruart and Jos{\'e} Mar{\'i}a Delgado-Garc{\'i}a and N{\`a}dia Villacampa and Antonietta Vilella and Markus J Hofer and Juan Hidalgo and Iain L Campbell and Berta Gonz{\'a}lez and Bernardo Castellano},
  journal={Brain, behavior, and immunity},
  year={2015},
  volume={45},
  pages={80-97}
}
Interleukin-10 (IL-10) is a cytokine classically linked with anti-inflammatory and protective functions in the central nervous system (CNS) in different neurodegenerative and neuroinflammatory conditions. In order to study the specific role of local CNS produced IL-10, we have created a new transgenic mouse line with astrocyte-targeted production of IL-10… CONTINUE READING