Alterations in membrane lipid dynamics of leukemic cells undergoing growth arrest and differentiation: dependency on the inducing agent.

@article{Nathan1998AlterationsIM,
  title={Alterations in membrane lipid dynamics of leukemic cells undergoing growth arrest and differentiation: dependency on the inducing agent.},
  author={Ilana Nathan and I Ben-Valid and R Henzel and H Masalha and S N Baram and Alexander Dvilansky and Abraham H. Parola},
  journal={Experimental cell research},
  year={1998},
  volume={239 2},
  pages={442-6}
}
The effect of various differentiation inducers on membrane cell dynamics was studied using HL-60 and K562 leukemic cell lines. Membrane lipid dynamics was measured by the steady-state fluorescence polarization (P) method utilizing either 1,6-diphenyl-1,3,5-hexatriene (DPH) or the trimethyl ammonium derivative of DPH (TMA-DPH), which ascertains anchorage of the label to the membrane-water-lipid interface. Decrease in membrane microfluidity was observed in HL-60 cells undergoing differentiation… CONTINUE READING
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