Alterations in local chromatin environment are involved in silencing and activation of subtelomeric var genes in Plasmodium falciparum

@article{Voss2007AlterationsIL,
  title={Alterations in local chromatin environment are involved in silencing and activation of subtelomeric var genes in Plasmodium falciparum},
  author={Till S Voss and Christopher J. Tonkin and Allison J. Marty and Jennifer K. Thompson and Julie Healer and Brendan Crabb and Alan F Cowman},
  journal={Molecular Microbiology},
  year={2007},
  volume={66},
  pages={139 - 150}
}
Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), encoded by the var gene family, undergoes antigenic variation and plays an important role in chronic infection and severe malaria. Only a single var gene is transcribed per parasite, and epigenetic control mechanisms are fundamental in this strategy of mutually exclusive transcription. We show that subtelomeric upsB var gene promoters carried on episomes are silenced by default, and that promoter activation is sufficient to silence… CONTINUE READING