Alterations in left ventricular diastolic function with doxorubicin therapy.

  title={Alterations in left ventricular diastolic function with doxorubicin therapy.},
  author={Byoung Ho Lee and Lucy S. Goodenday and Gary Muswick and William A. Yasnoff and Richard F. Leighton and Roland T. Skeel},
  journal={Journal of the American College of Cardiology},
  volume={9 1},
To determine whether impaired diastolic function may be an early sign of doxorubicin cardiotoxicity, a retrospective study was performed in 12 patients who had undergone serial radionuclide angiography and were found to have a left ventricular ejection fraction of 55% or more before doxorubicin (Adriamycin) treatment and during follow-up. Average rapid filling velocity and slow filling velocity were both significantly reduced after doxorubicin treatment. Rapid filling velocity decreased from 5… CONTINUE READING


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