Alterations in ionotropic glutamate receptor subunits during binge cocaine self-administration and withdrawal in rats.

@article{Tang2004AlterationsII,
  title={Alterations in ionotropic glutamate receptor subunits during binge cocaine self-administration and withdrawal in rats.},
  author={Wenxue Tang and Michael J. Wesley and Willard M Freeman and Bill Liang and Scott E Hemby},
  journal={Journal of neurochemistry},
  year={2004},
  volume={89 4},
  pages={1021-33}
}
Chronic cocaine use in humans and animal models is known to lead to pronounced alterations in glutamatergic function in brain regions associated with reinforcement. Previous studies have examined ionotropic glutamate receptor (iGluR) subunit protein level changes following acute and chronic experimenter-administered cocaine or after withdrawal periods from experimenter-administered cocaine. To evaluate whether alterations in expression of iGluRs are associated with cocaine reinforcement… CONTINUE READING

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