Alterations in intrinsic membrane properties and the axon initial segment in a mouse model of Angelman syndrome.

@article{Kaphzan2011AlterationsII,
  title={Alterations in intrinsic membrane properties and the axon initial segment in a mouse model of Angelman syndrome.},
  author={Hanoch Kaphzan and Shelly A Buffington and Joo In Jung and Matthew N Rasband and Eric Klann},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2011},
  volume={31 48},
  pages={17637-48}
}
The axon initial segment (AIS) is the site of action potential initiation in neurons. Recent studies have demonstrated activity-dependent regulation of the AIS, including homeostatic changes in AIS length, membrane excitability, and the localization of voltage-gated Na(+) channels. The neurodevelopmental disorder Angelman syndrome (AS) is usually caused by the deletion of small portions of the maternal copy of chromosome 15, which includes the UBE3A gene. A mouse model of AS has been generated… CONTINUE READING
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