Alterations in intracellular calcium compartmentation following inhibition of calcium efflux from isolated hepatocytes.

Abstract

Addition of ATP to the incubation medium of freshly isolated rat hepatocytes causes a marked inhibition of the efflux of Ca2+ from the cells, and its accumulation in intracellular compartments. After an initial rise in cytosolic free Ca2+ concentration, as indicated by the activation of phosphorylase, Ca2+ is preferentially sequestered in the mitochondria… (More)

Topics

  • Presentations referencing similar topics