Alterations in insulin receptor signalling in the rat epitrochlearis muscle upon cessation of voluntary exercise.

@article{Kump2005AlterationsII,
  title={Alterations in insulin receptor signalling in the rat epitrochlearis muscle upon cessation of voluntary exercise.},
  author={David S Kump and Frank W Booth},
  journal={The Journal of physiology},
  year={2005},
  volume={562 Pt 3},
  pages={829-38}
}
The major purpose of this study was to elucidate mechanisms by which decreasing enhanced physical activity induces decreased insulin sensitivity in skeletal muscle. Rats with access to voluntary running wheels for 3 weeks had their wheels locked for 5 h (WL5), 29 h (WL29), or 53 h (WL53); a separate group of rats never had wheel access (sedentary, SED). Relative to WL5, submaximal insulin-stimulated 2-deoxyglucose uptake into the epitrochlearis muscle was lower in WL53 and SED. Insulin binding… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 45 extracted citations

Similar Papers

Loading similar papers…