Alterations in hypothalamic-pituitary-adrenal function correlated with the onset of murine SLE in MRL +/+ and lpr/lpr mice.

@article{Shanks1999AlterationsIH,
  title={Alterations in hypothalamic-pituitary-adrenal function correlated with the onset of murine SLE in MRL +/+ and lpr/lpr mice.},
  author={Nola Shanks and Patricia M. Moore and Paula Perks and Susan L. Lightman},
  journal={Brain, behavior, and immunity},
  year={1999},
  volume={13 4},
  pages={348-60}
}
Systemic lupus erythematosus (SLE) is a spontaneously occurring, chronic autoimmune disease that can manifest neuropsychiatric abnormalities. The pathways mediating these central changes are not known; however, neuroendocrine alterations associated with inflammation may play a role. Predisposition to and progression of autoimmune disease has been associated with altered hypothalamic-pituitary-adrenal (HPA) function and inflammation has been reported to alter hypothalamic regulation of HPA… CONTINUE READING
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