Alterations in hepatocyte insulin binding in chronic pancreatitis: effects of pancreatic polypeptide.

@article{Seymour1995AlterationsIH,
  title={Alterations in hepatocyte insulin binding in chronic pancreatitis: effects of pancreatic polypeptide.},
  author={Neal E. Seymour and Amy Volpert and Edward L. Lee and Dana K. Andersen and Caridad Mar{\'i}n Hern{\'a}ndez},
  journal={American journal of surgery},
  year={1995},
  volume={169 1},
  pages={105-9; discussion 110}
}
BACKGROUND Hepatic insulin resistance has previously been demonstrated in chronic pancreatitis, and has been shown to be ameliorated by pancreatic polypeptide administration. Insulin binding was investigated in chronic pancreatitis induced by infusion of oleic acid into the pancreatic duct of rats. METHODS Acute pancreatitis was induced in 12 200 to 225 g 8-week-old male Sprague-Dawley rats by intubation of the main bile duct at its junction with the duodenum through a small midline abdominal… CONTINUE READING

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