Alterations in hepatic metabolism in fld mice reveal a role for lipin 1 in regulating VLDL-triacylglyceride secretion.

@article{Chen2008AlterationsIH,
  title={Alterations in hepatic metabolism in fld mice reveal a role for lipin 1 in regulating VLDL-triacylglyceride secretion.},
  author={Zhouji Chen and Matthew C. Gropler and Jin Yi Norris and John C. Lawrence and Thurl E. Harris and Brian N Finck},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2008},
  volume={28 10},
  pages={
          1738-44
        }
}
OBJECTIVE Lipin 1 controls fatty acid metabolism in the nucleus as a transcriptional regulator and in the cytosol as an enzyme catalyzing the penultimate step in phosphoglycerol triacylglyceride (TAG) synthesis. We sought to evaluate the effects of lipin 1 on hepatic TAG synthesis and secretion by gain-of-function and loss-of-function approaches. METHODS AND RESULTS Rates of TAG synthesis were not impaired in hepatocytes isolated from adult lipin 1-deficient (fld) mice and were actually… CONTINUE READING

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