Alterations in heart membrane calcium transport during the development of ischemia-reperfusion injury.

@article{Dhalla1988AlterationsIH,
  title={Alterations in heart membrane calcium transport during the development of ischemia-reperfusion injury.},
  author={Naranjan S. Dhalla and Vincenzo Panagia and Pawan K. Singal and Naoki Makino and Ian M. C. Dixon and D. A. Eyolfson},
  journal={Journal of molecular and cellular cardiology},
  year={1988},
  volume={20 Suppl 2},
  pages={3-13}
}
Global ischemia in guinea-pig hearts for 60 to 90 min depressed microsomal and mitochondrial Ca2+ uptake activities. Reperfusion of the 60 min ischemic hearts resulted in incomplete recovery of contractile function and calcium uptake activities of both mitochondrial and microsomal fractions. On the other hand, reperfusion of the 90 min ischemic hearts further depressed the microsomal Ca2+ uptake activity. Coronary occlusion for 90 min in dog hearts was found to decrease microsomal Ca2+-pump and… CONTINUE READING
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