Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia.

@article{Sian1994AlterationsIG,
  title={Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia.},
  author={Jos{\'e} E Sian and David T Dexter and A. J. Lees and Susan E Daniel and Yves Agid and France Javoy-Agid and P Feroz Jenner and C. David Marsden},
  journal={Annals of neurology},
  year={1994},
  volume={36 3},
  pages={348-55}
}
Reduced glutathione (GSH) and oxidized glutathione (GSSG) levels were measured in various brain areas (substantia nigra, putamen, caudate nucleus, globus pallidus, and cerebral cortex) from patients dying with Parkinson's disease, progressive supranuclear palsy, multiple-system atrophy, and Huntington's disease and from control subjects with no neuropathological changes in substantia nigra. GSH levels were reduced in substantia nigra in Parkinson's disease patients (40% compared to control… CONTINUE READING
Highly Influential
This paper has highly influenced 14 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 339 extracted citations

Conditioning Against the Pathology of Parkinson's disease.

Conditioning medicine • 2018
View 4 Excerpts
Highly Influenced

Glutathione deficiency in Gclm null mice results in complex I inhibition and dopamine depletion following paraquat administration.

Toxicological sciences : an official journal of the Society of Toxicology • 2013
View 3 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…