Alterations in glutamate but not GABAA receptor subunit expression as a consequence of epileptiform activity in vitro.

@article{GerfinMoser1995AlterationsIG,
  title={Alterations in glutamate but not GABAA receptor subunit expression as a consequence of epileptiform activity in vitro.},
  author={A Gerfin-Moser and F. Grogg and Lotty Rietschin and Scott M. Thompson and Peter Streit},
  journal={Neuroscience},
  year={1995},
  volume={67 4},
  pages={849-65}
}
The consequences of epileptiform discharge on the expression of glutamate and GABA receptors were examined by in situ hybridization histochemistry after treatment of rat hippocampal slice cultures with convulsants. Application of 500 microM picrotoxin for two days led to decreases in the messenger RNA levels for the N-methyl-D-aspartate receptor subunits, NR2A and NR2B, and for the non-N-methyl-D-aspartate receptor subunits, glutamate receptors 1 and glutamate receptors 2, to about 50% of the… CONTINUE READING
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