Alterations in glucocorticoid negative feedback following maternal Pb, prenatal stress and the combination: a potential biological unifying mechanism for their corresponding disease profiles.

@article{RossiGeorge2009AlterationsIG,
  title={Alterations in glucocorticoid negative feedback following maternal Pb, prenatal stress and the combination: a potential biological unifying mechanism for their corresponding disease profiles.},
  author={Alba Rossi-George and Miriam Beatriz Virgolini and Douglas D Weston and Deborah A. Cory-Slechta},
  journal={Toxicology and applied pharmacology},
  year={2009},
  volume={234 1},
  pages={117-27}
}
Combined exposures to maternal lead (Pb) and prenatal stress (PS) can act synergistically to enhance behavioral and neurochemical toxicity in offspring. Maternal Pb itself causes permanent dysfunction of the body's major stress system, the hypothalamic pituitary adrenal (HPA) axis. The current study sought to determine the potential involvement of altered negative glucocorticoid feedback as a mechanistic basis of the effects in rats of maternal Pb (0, 50 or 150 ppm in drinking water beginning 2… CONTINUE READING