Alterations in function and phenotype of monocytes from patients with septic disease--predictive value and new therapeutic strategies.

@article{Volk1991AlterationsIF,
  title={Alterations in function and phenotype of monocytes from patients with septic disease--predictive value and new therapeutic strategies.},
  author={Hans Dieter Volk and Marcus Thieme and S Heym and W. D. D{\"o}cke and U Ruppe and W. Tausch and D. K. Manger and S Zuckermann and A. Golosubow and B. Nieter},
  journal={Behring Institute Mitteilungen},
  year={1991},
  volume={88},
  pages={
          208-15
        }
}
Recently we described the predictive value of the proportion of HLA-DR+ peripheral blood monocytes for the clinical outcome of septic disease in immunosuppressed patients (allograft recipients) and surgical patients mostly with peritonitis as septic focus (following perforation of gastrointestinal tract). The experiments described here show that the loss of HLA-class II antigen expression and other phenotypical abnormalities of monocytes from septic patients with fatal outcome are associated… CONTINUE READING

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