Alterations in frontal white matter neurochemistry and microstructure in schizophrenia: implications for neuroinflammation

@inproceedings{Chiappelli2015AlterationsIF,
  title={Alterations in frontal white matter neurochemistry and microstructure in schizophrenia: implications for neuroinflammation},
  author={Joshua J Chiappelli and Liyi Elliot Hong and S. A. Wijtenburg and Xiaoming Du and Frank E Gaston and Peter V. Kochunov and Laura Rowland},
  booktitle={Translational Psychiatry},
  year={2015}
}
We investigated in vivo neurochemical markers reflective of neuronal health and glial activation to determine if these could yield clues regarding the reduced fractional anisotropy (FA) of white matter and accelerated decline of FA with age in schizophrenia. Participants with schizophrenia and healthy controls completed diffusion tensor imaging to assess FA and proton magnetic resonance spectroscopy to assess neurochemical metabolites in the same frontal region. Frontal FA was significantly… CONTINUE READING
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