Alterations in filarial antigen-specific immunologic reactivity following treatment with ivermectin and diethylcarbamazine.

@article{Lammie1992AlterationsIF,
  title={Alterations in filarial antigen-specific immunologic reactivity following treatment with ivermectin and diethylcarbamazine.},
  author={Patrick J. Lammie and Allen W. Hightower and Frank O. Richards and Ralph T. Bryan and Henry Cecil Spencer and D F McNeeley and M B McNeeley and Mark L. Eberhard},
  journal={The American journal of tropical medicine and hygiene},
  year={1992},
  volume={46 3},
  pages={
          292-5
        }
}
The presence of circulating microfilariae has been associated with alterations in B and T cell functions. In this study, we compared the influence of diethylcarbamazine (DEC) and ivermectin on filarial antigen-specific immune responses in a Haitian population. Both drugs were effective at reducing microfilaremia levels to less than 10% of pretreatment levels for up to one year. This reduction in microfilaremia was associated with two phases of altered cellular responsiveness monitored with in… CONTINUE READING

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