Alterations in exocytosis induced by neuronal Ca2+ sensor-1 in bovine chromaffin cells.

@article{Pan2002AlterationsIE,
  title={Alterations in exocytosis induced by neuronal Ca2+ sensor-1 in bovine chromaffin cells.},
  author={Chien-Yuan Pan and Andreas Jeromin and Kenneth Lundstrom and Seung Hyun Yoo and John Roder and Aaron Patrick Fox},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2002},
  volume={22 7},
  pages={
          2427-33
        }
}
A variety of Ca2+ binding proteins are known to play an integral role in catecholamine release from synapses as well as secretory cells, such as chromaffin cells. The Drosophila protein frequenin and its mammalian homolog neuronal Ca2+ sensor-1 (NCS-1) belong to a family of Ca2+ sensors with EF hands that bind Ca2+ and then interact with other proteins. Frequenin/NCS-1 has been shown to enhance exocytotic activity in addition to altering Ca2+ channel regulation. To better understand how NCS-1… CONTINUE READING

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