Alterations in estradiol metabolism in MCF-7 cells induced by treatment with indole-3-carbinol and related compounds.

Abstract

In mammals, estradiol (E2) metabolism primarily involves mutually exclusive hydroxylation at either C-2 or C-16 alpha. We have previously reported a consistent increase in the C-16 alpha hydroxylation activity in human breast cancer and in mouse strains with high levels of mammary tumors. Here we show that the dietary compound indole-3-carbinol (I3C… (More)

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