Alterations in epithelial barrier function and host defense responses in chronic rhinosinusitis.


Chronic rhinosinusitis (CRS) is characterized by a chronic symptomatic inflammation of the nasal and paranasal sinus mucosae and is one of the most frequently reported chronic diseases in the United States, with an estimated prevalence of greater than 10% of the general population. Although the pathogenesis of CRS remains poorly understood, there is… (More)
DOI: 10.1016/j.jaci.2009.04.045


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