Alterations in epidermal functions resulting from exposure to initiators and promoters of carcinogenesis.

@article{Yuspa1983AlterationsIE,
  title={Alterations in epidermal functions resulting from exposure to initiators and promoters of carcinogenesis.},
  author={Stuart H. Yuspa},
  journal={Current problems in dermatology},
  year={1983},
  volume={11},
  pages={227-41}
}
Mouse epidermal basal cells can be selectively cultivated in medium with a [Ca++] of 0.02-0.09 mM. Terminal differentiation and sloughing of mature keratinocytes occurs when the [Ca++] is increased to 1.2-1.4 mM. When basal cell cultures are exposed to chemical initiators of carcinogenesis, colonies of cells which resist Ca++ -induced differentiation evolve. Likewise basal cells derived from mouse skin initiated in vivo yield foci which resist terminal differentiation. This defect in the… CONTINUE READING