Alterations in electroretinograms and retinal morphology in rabbits treated with vigabatrin

  title={Alterations in electroretinograms and retinal morphology in rabbits treated with vigabatrin},
  author={Vesna Ponjavic and Lotta Gr{\"a}nse and Sten Kjellstr{\"o}m and Sten O. L. Andreasson and Anitha Bruun},
  journal={Documenta Ophthalmologica},
Purpose: To determine whether long-term treatment with the anti-epileptic drug vigabatrin causes damage to rabbit retina. Methods: Five rabbits were treated continuously with a daily dose of vigabatrin solution per orally during a period of 1–8 months. Two rabbits receiving water were used as controls. Repeated full-field electroretinograms (every two weeks) were assessed during this period. Vigabatrin serum concentration was repeatedly measured for securing successful drug administration… CONTINUE READING


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