Alterations in electrical and contractile behavior of isolated cardiomyocytes by hydrogen peroxide: possible ionic mechanisms.

@article{Bersewicz1991AlterationsIE,
  title={Alterations in electrical and contractile behavior of isolated cardiomyocytes by hydrogen peroxide: possible ionic mechanisms.},
  author={Andrzej Beręsewicz and Magda Horackova},
  journal={Journal of molecular and cellular cardiology},
  year={1991},
  volume={23 8},
  pages={
          899-918
        }
}
The development of H2O2-induced changes in membrane potentials, membrane currents and corresponding contractile activity (shortening) were studied in rat and guinea-pig ventricular myocytes using the suction-pipette whole-cell clamp method. The cells exhibited a different sensitivity to 30 microM H2O2 in terms of time development of the changes, which were fully irreversible. The observed changes are described in three phases: (1) prolongation of action potential duration (APD) accompanied by… CONTINUE READING
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