Alterations in dynamic heart rate control in the β1-adrenergic receptor knockout mouse.

@article{Rohrer1998AlterationsID,
  title={Alterations in dynamic heart rate control in the β1-adrenergic receptor knockout mouse.},
  author={Daniel K. Rohrer and Eric H. Schauble and Kavin H Desai and Brian K. Kobilka and D. Bernstein},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={1998},
  volume={274 4},
  pages={H1184-H1193}
}
β1-Adrenergic receptors (β1-ARs) are key targets of sympathetic nervous system activity and play a major role in the beat-to-beat regulation of cardiac chronotropy and inotropy. We employed a β1-AR gene knockout model to test the hypothesis that β1-AR function is critical for maintenance of resting heart rate and baroreflex responsiveness and, on the basis of its important role in regulating chronotropy and inotropy, is also required for maximal exercise capacity. Using an awake unrestrained… CONTINUE READING

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Diminished contractile response to isoproterenol in beta-1 adrenergic receptor deficient mice (Abstract)

  • K. H. Desai, D. K. Rohrer, B. K. Kobilka, D. Bernstein
  • Circulation 94, Suppl.:
  • 1996
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