Alterations in dorsal horn neurones in a rat model of cancer-induced bone pain

@article{Urch2003AlterationsID,
  title={Alterations in dorsal horn neurones in a rat model of cancer-induced bone pain},
  author={Catherine E. Urch and Tansy Donovan-Rodr{\'i}guez and Anthony Henry Dickenson},
  journal={Pain},
  year={2003},
  volume={106},
  pages={347-356}
}
Cancer-induced bone pain is a major clinical problem. A rat model based on intra-tibial injection of MRMT-1 mammary tumour cells was used to mimic progressive cancer-induced bone pain. At the time of stable behavioural changes (decreased thresholds to mechanical and cold stimuli) and bone destruction, in vivo electrophysiology was used to characterize natural (mechanical, thermal, and cold) and electrical-evoked responses of superficial and deep dorsal horn neurones in halothane-anaesthetized… CONTINUE READING
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