Alterations in deoxyribonucleic acid (DNA) methylation patterns of Calca, Timp3, Mmp2, and Igf2r are associated with chronic cystitis in a cyclophosphamide-induced mouse model.

@article{Choi2013AlterationsID,
  title={Alterations in deoxyribonucleic acid (DNA) methylation patterns of Calca, Timp3, Mmp2, and Igf2r are associated with chronic cystitis in a cyclophosphamide-induced mouse model.},
  author={In-Seon Choi and Kevin Yu and JaYoung Kim and Erika de Guzman and Daniel J. Weisenberger and Shirley Oghamian and Hee Ju Kim and Kyung Hwa Lee and Cindy A Carroll and Binh N. Trinh and Myungjin Kim and Sahar Houshdaran and Peter W. Laird and Peter A. Jones and David Warburton and Gangning Liang and Chester J. Koh},
  journal={Urology},
  year={2013},
  volume={82 1},
  pages={253.e9-15}
}
OBJECTIVE To determine whether epigenetic changes occur during cyclophosphamide-induced chronic bladder inflammation in mice. MATERIALS AND METHODS Epigenetic changes play a role in the regulation of inflammatory genes in noncancer diseases such as asthma and chronic obstructive pulmonary disease. However, epigenetic (deoxyribonucleic acid [DNA] methylation) changes during chronic bladder inflammation have not been previously described. Chronic cystitis was induced in 3 groups of adult CD-1… CONTINUE READING
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