Alterations in cyclosporin A pharmacokinetics and metabolism during treatment with St John's wort in renal transplant patients.

@article{Bauer2003AlterationsIC,
  title={Alterations in cyclosporin A pharmacokinetics and metabolism during treatment with St John's wort in renal transplant patients.},
  author={Steffen Bauer and Elke St{\"o}rmer and Andreas Johne and Hagen Krueger and Klemens Budde and Hans-Hellmut Neumayer and Ivar Roots and Ingrid Mai},
  journal={British journal of clinical pharmacology},
  year={2003},
  volume={55 2},
  pages={
          203-11
        }
}
AIM This study investigated the effects of St John's wort extract (SJW) on the pharmacokinetics and metabolism of the immunosuppressant cyclosporin A (CSA). METHODS In an open-label study, 11 renal transplant patients received 600 mg SJW extract daily for 14 days in addition to their regular regimen of CSA. Blood concentrations of CSA and its metabolites AM1, AM1C, AM9, AM19, and AM4N were measured by HPLC. RESULTS After 2 weeks of SJW coadministration, dose-corrected AUC0-12, Cmax and… CONTINUE READING

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