Alterations in content and phosphorylation state of cytoskeletal proteins in the sciatic nerve during ageing and in Alzheimer's disease

@article{Holzer1999AlterationsIC,
  title={Alterations in content and phosphorylation state of cytoskeletal proteins in the sciatic nerve during ageing and in Alzheimer's disease},
  author={Max Holzer and H Holzapfel and Knut Krohn and H. -J. Gertz and Th. Arendt},
  journal={Journal of Neural Transmission},
  year={1999},
  volume={106},
  pages={743-755}
}
Paired helical filaments containing the microtubule-associated protein tau in an abnormally high phosphorylated state are one of the major hallmarks of Alzheimer's disease. In the central nervous system, this neurofibrillar degeneration preferentially affects long-axon projection neurons. In the peripheral nervous system largely made up by long-axon neurons, formation of paired helical filaments, however, has only rarely been described. In the present study, we have analysed alterations in the… CONTINUE READING

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