Alterations in circulating osteoimmune factors may be responsible for high bone resorption rate in HIV-infected children and adolescents.

Abstract

OBJECTIVES Bone metabolism derangements have been reported in HIV-infected children and adolescents. Nuclear factor kappa B ligand (RANKL) and osteoprotegerin potently stimulate and inhibit, respectively, osteoclast formation and activity. We investigated the possible role of RANKL and osteoprotegerin on bone metabolism alterations in paediatric patients… (More)

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