Alterations in circulating blood volume during polymicrobial sepsis.

  title={Alterations in circulating blood volume during polymicrobial sepsis.},
  author={Ping Wang and Zheng F. Ba and Saskia Tait and Mian Zhou and Irshad H. Chaudry},
  journal={Circulatory shock},
  volume={40 2},
Although a great deal is known concerning the pathophysiology of sepsis, it is not clear whether circulating blood volume (CBV) is altered under such conditions. To study, this, rats were subjected to sepsis by cecal ligation and puncture (CLP). Immediately after CLP or sham operation, the animals received 3 ml/100 g body weight normal saline subcutaneously. CBV was determined by using in vivo indocyanine green (ICG) clearance at 2, 5, 10, or 20 hr after CLP or sham operation. This technique… CONTINUE READING