Alterations in chondroitin sulfate proteoglycan expression occur both at and far from the site of spinal contusion injury.

@article{Andrews2012AlterationsIC,
  title={Alterations in chondroitin sulfate proteoglycan expression occur both at and far from the site of spinal contusion injury.},
  author={Ellen M. Andrews and Rebekah J Richards and Feng Qin Yin and Mariano Sebastian Viapiano and Lyn B. Jakeman},
  journal={Experimental neurology},
  year={2012},
  volume={235 1},
  pages={174-87}
}
Chondroitin sulfate proteoglycans (CSPGs) present an inhibitory barrier to axonal growth and plasticity after trauma to the central nervous system. These extracellular and membrane bound molecules are altered after spinal cord injuries, but the magnitude, time course, and patterns of expression following contusion injury have not been fully described. Western blots and immunohistochemistry were combined to assess the expression of four classically inhibitory CSPGs, aggrecan, neurocan, brevican… CONTINUE READING

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These extracellular and membrane bound molecules are altered after spinal cord injuries , but the magnitude , time course , and patterns of expression following contusion injury have not been fully described .
These extracellular and membrane bound molecules are altered after spinal cord injuries , but the magnitude , time course , and patterns of expression following contusion injury have not been fully described .
Western blots and immunohistochemistry were combined to assess the expression of four classically inhibitory CSPGs , aggrecan , neurocan , brevican and NG2 , at the lesion site and in distal segments of cervical and thoracic spinal cord at 3 , 7 , 14 and 28 days following a severe mid - thoracic spinal contusion .
In contrast , aggrecan and brevican were sharply reduced at the injury site and were unchanged in distal segments .
Western blots and immunohistochemistry were combined to assess the expression of four classically inhibitory CSPGs , aggrecan , neurocan , brevican and NG2 , at the lesion site and in distal segments of cervical and thoracic spinal cord at 3 , 7 , 14 and 28 days following a severe mid - thoracic spinal contusion .
In contrast , aggrecan and brevican were sharply reduced at the injury site and were unchanged in distal segments .
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