Alterations in cellular metabolism modulate CD1d-mediated NKT-cell responses.

  title={Alterations in cellular metabolism modulate CD1d-mediated NKT-cell responses.},
  author={Tonya J Roberts Webb and Gregory B. Carey and James East and Wenji Sun and Dominique R. Bollino and A. Samuel Kimball and Randy R. Brutkiewicz},
  journal={Pathogens and disease},
  volume={74 6}
Natural killer T (NKT) cells play a critical role in the host's innate immune response. CD1d-mediated presentation of glycolipid antigens to NKT cells has been established; however, the mechanisms by which NKT cells recognize infected or cancerous cells remain unclear. 5(')-AMP activated protein kinase (AMPK) is a master regulator of lipogenic pathways. We hypothesized that activation of AMPK during infection and malignancy could alter the repertoire of antigens presented by CD1d and serve as a… CONTINUE READING
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