Alterations in cardiac gene expression during the transition from stable hypertrophy to heart failure. Marked upregulation of genes encoding extracellular matrix components.

@article{Boluyt1994AlterationsIC,
  title={Alterations in cardiac gene expression during the transition from stable hypertrophy to heart failure. Marked upregulation of genes encoding extracellular matrix components.},
  author={Marvin O. Boluyt and Linda O'Neill and Andrea L Meredith and Oscar H. L. Bing and W. Douglas Brooks and Chester Conrad and Michael T. Crow and Edward G. Lakatta},
  journal={Circulation research},
  year={1994},
  volume={75 1},
  pages={23-32}
}
The failing heart is characterized by impaired cardiac muscle function and increased interstitial fibrosis. Our purpose was to determine whether the functional impairment of the failing heart is associated with changes in levels of mRNA encoding proteins that modulate parameters of contraction and relaxation and whether the increased fibrosis observed in the failing heart is related to elevated expression of genes encoding extracellular matrix components. We studied hearts of 18- to 24-month… CONTINUE READING

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