Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy.

@article{Freeman2001AlterationsIC,
  title={Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy.},
  author={Kristen R Freeman and Israel Lerman and Evangelia G Kranias and Teresa Bohlmeyer and Michael R. Bristow and Robert J Lefkowitz and Guido Iaccarino and Walter J Koch and L. A. Leinwand},
  journal={The Journal of clinical investigation},
  year={2001},
  volume={107 8},
  pages={967-74}
}
The medical treatment of chronic heart failure has undergone a dramatic transition in the past decade. Short-term approaches for altering hemodynamics have given way to long-term, reparative strategies, including beta-adrenergic receptor (betaAR) blockade. This was once viewed as counterintuitive, because acute administration causes myocardial depression. Cardiac myocytes from failing hearts show changes in betaAR signaling and excitation-contraction coupling that can impair cardiac… CONTINUE READING
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