Alterations in brain metabolism and function following administration of low-dose codeine phosphate: 1H-magnetic resonance spectroscopy and resting-state functional magnetic resonance imaging studies

@article{Cao2016AlterationsIB,
  title={Alterations in brain metabolism and function following administration of low-dose codeine phosphate: 1H-magnetic resonance spectroscopy and resting-state functional magnetic resonance imaging studies},
  author={Zhen Cao and Pei-yin Lin and Zhiwei Shen and R. H. Wu and Yeyu Xiao},
  journal={Experimental and Therapeutic Medicine},
  year={2016},
  volume={12},
  pages={619 - 626}
}
  • Zhen Cao, P. Lin, +2 authors Yeyu Xiao
  • Published 18 May 2016
  • Chemistry, Medicine
  • Experimental and Therapeutic Medicine
The aim of the present study was to identify alterations in brain function following administration of a single, low-dose of codeine phosphate in healthy volunteers using resting-state functional magnetic resonance imaging (fMRI). In addition, the metabolic changes in the two sides of the frontal lobe were identified using 1H-magnetic resonance spectroscopy (1H-MRS). A total of 20 right-handed healthy participants (10 males, 10 females) were evaluated, and a Signa HDx 1.5T MRI scanner was used… 

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