Alterations in brain dopamine and GABA following inorganic or organic manganese administration.

@article{Gianutsos1982AlterationsIB,
  title={Alterations in brain dopamine and GABA following inorganic or organic manganese administration.},
  author={Gerald Gianutsos and Mary T. Murray},
  journal={Neurotoxicology},
  year={1982},
  volume={3 3},
  pages={75-81}
}
Administration of manganese to mice in the form of MnCl2 (4%) in the diet for 6 months or injections of the organic fuel-additive methylcyclopentadienyl manganese tricarbonyl (MMT) for 3 weeks resulted in a decrease in dopamine concentrations in the striatum and olfactory tubercles. The GABA content of the striatum was elevated after either treatment while the cerebellar GABA content did not change; GABA in the substantia nigra of MMT-treated mice was also increased. Choline acetyltransferase… CONTINUE READING

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