Alterations in brain aldehyde dehydrogenase activity modify ethanol-induced conditioned taste aversion.

  title={Alterations in brain aldehyde dehydrogenase activity modify ethanol-induced conditioned taste aversion.},
  author={Karen J Spivak and Carlos M. G. Arag{\'o}n and Zalman Amit},
  journal={Alcoholism, clinical and experimental research},
  volume={11 6},
The role of peripherally and centrally acting acetaldehyde in ethanol-induced conditioned taste aversion (CTA) was investigated using various enzyme manipulations. Cyanamide, an aldehyde dehydrogenase inhibitor (ALDH) elevates blood acetaldehyde levels in the presence of ethanol. Concurrent administration with 4-methylpyrazole (4MP), an alcohol dehydrogenase inhibitor, prevents peripheral accumulation of acetaldehyde by cyanamide. Under both treatment conditions brain and liver ALDH activity is… 

Role of acetaldehyde in ethanol-induced conditioned taste aversion in rats

It is suggested that the reinforcing effects of brain acetaldehyde might actually reduce ethanol-induced CTA, and the inhibition of brain catalase activity may contribute to the potentiating effects of cyanamide on ethanol- induced CTA.

Concurrent administration of diethyldithiocarbamate and 4-methylpyrazole enhances ethanol-induced locomotor activity: the role of brain ALDH

The data suggest that brain ALDH may contribute to the effects of ethanol on locomotor activity, as pretreatment with 4-MP prevented peripheral accumulation of acetaldehyde.

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It is suggested that cyanamide could reduce locomotor activity through its inhibition of brain catalase, giving further support to the notion that brainCatalase may be an important regulator of some ethanol-induced behavioural effects.

Taurine and ethanol-induced conditioned taste aversion

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It is proposed that the possible mechanism by which the i.p. injection of ethanol to UChB rats induces an increase in ethanol consumption is the development of acute tolerance, where acetaldehyde formed during brain ethanol metabolism via catalase and its subsequent oxidation via aldehyde dehydrogenase have an important role.

Ontogenetic difference in ethanol reinforcing properties: the role of the opioid system

The results indicate that the increased ethanol acceptance induced by ethanol intoxication in the younger pups is mediated by the opioid system, and that ethanol may also induce conditioned aversions at this early age.

Effects of 3-amino-1,2,4-triazole on ethanol-induced open-field activity: evidence for brain catalase mediation of ethanol's effects.

The results of the present study suggest that brain catalase activity may be involved in ethanol's effects and provide further support for the notion that acetaldehyde may be produced directly in the brain viaCatalase and that it may be a factor mediating some of ethanol's central effects.

Behavioral and biochemical evidence of the role of acetaldehyde in the motivational effects of ethanol

The behavioral and biochemical evidence reviewed points to ACD as a neuroactive molecule able, on its own and as ethanol metabolite, to exert motivational effects.



4-Methylpyrazole as an inhibitor of ethanol metabolism: differential metabolic and central nervous effects.

4-MP exerts significant central depressant effects per se, and produces an enhancement and a prolongation of ethanol-induced effects on coordination in the rat, which is significant in all conditions, when compared to the controls.