Alterations in brain aldehyde dehydrogenase activity modify ethanol-induced conditioned taste aversion.

@article{Spivak1987AlterationsIB,
  title={Alterations in brain aldehyde dehydrogenase activity modify ethanol-induced conditioned taste aversion.},
  author={Karen J Spivak and Carlos M. G. Arag{\'o}n and Zalman Amit},
  journal={Alcoholism, clinical and experimental research},
  year={1987},
  volume={11 6},
  pages={
          513-7
        }
}
The role of peripherally and centrally acting acetaldehyde in ethanol-induced conditioned taste aversion (CTA) was investigated using various enzyme manipulations. Cyanamide, an aldehyde dehydrogenase inhibitor (ALDH) elevates blood acetaldehyde levels in the presence of ethanol. Concurrent administration with 4-methylpyrazole (4MP), an alcohol dehydrogenase inhibitor, prevents peripheral accumulation of acetaldehyde by cyanamide. Under both treatment conditions brain and liver ALDH activity is… 

Role of acetaldehyde in ethanol-induced conditioned taste aversion in rats

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4-MP exerts significant central depressant effects per se, and produces an enhancement and a prolongation of ethanol-induced effects on coordination in the rat, which is significant in all conditions, when compared to the controls.