Alterations in blood-brain barrier permeability to large and small molecules and leukocyte accumulation after traumatic brain injury: effects of post-traumatic hypothermia.

@article{Lotocki2009AlterationsIB,
  title={Alterations in blood-brain barrier permeability to large and small molecules and leukocyte accumulation after traumatic brain injury: effects of post-traumatic hypothermia.},
  author={George Lotocki and Juan Pablo de Rivero Vaccari and Enrique Rosendo P{\'e}rez and Juliana S{\'a}nchez-Molano and Ofelia Furones-Alonso and Helen M. Bramlett and W. Dalton Dietrich},
  journal={Journal of neurotrauma},
  year={2009},
  volume={26 7},
  pages={1123-34}
}
We investigated the temporal and regional profile of blood-brain barrier (BBB) permeability to both large and small molecules after moderate fluid percussion (FP) brain injury in rats and determined the effects of post-traumatic modest hypothermia (33 degrees C/4 h) on these vascular perturbations. The visible tracers biotin-dextrin-amine 3000 (BDA-3K, 3 kDa) and horseradish peroxidase (HRP, 44 kDa) were injected intravenously at 4 h or 3 or 7 days post-TBI. At 30 min after the tracer infusion… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 52 extracted citations

Similar Papers

Loading similar papers…