Alterations in bioenergetics due to changes in mitochondrial DNA copy number.

@article{Qian2010AlterationsIB,
  title={Alterations in bioenergetics due to changes in mitochondrial DNA copy number.},
  author={Wei Qian and Bennett van Houten},
  journal={Methods},
  year={2010},
  volume={51 4},
  pages={452-7}
}
All mitochondrial DNA (mtDNA)-encoded genes are involved in mitochondrial electron transport and ATP production. Alterations of mtDNA due to dysfunctional mitochondrial DNA polymerase gamma (POLG) induce loss of mitochondrial oxidative phosphorylation (OXPHOS) and mitochondrial ATP generation. Total intracellular ATP is generated by two energetic pathways… CONTINUE READING