Alterations in basement membrane immunoreactivity of the diabetic retina in three diabetic mouse models

@article{Abari2012AlterationsIB,
  title={Alterations in basement membrane immunoreactivity of the diabetic retina in three diabetic mouse models},
  author={Elizabeth Abari and Norbert Kociok and Ursula Hartmann and Irina Semkova and Mats Paulsson and Albert Lo and Antonia Maria Joussen},
  journal={Graefe's Archive for Clinical and Experimental Ophthalmology},
  year={2012},
  volume={251},
  pages={763-775}
}
The mouse retina contains three kinds of basement membrane (BM) structures; the inner limiting membrane (ILM), Bruch’s membrane (BrM), and the BM surrounding the capillaries. We aimed to investigate possible variations of individual BM components and to detect effects caused by diabetes in three different diabetic mouse models. After 4 and 6 months of diabetes (defined by blood glucose > 250 mg/dl), we analyzed by immunohistochemistry the laminin, collagen IV, and nidogen-1 and nidogen-2… CONTINUE READING

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