Alterations in autoregulatory and myogenic function in the cerebrovasculature of Dahl salt-sensitive rats.

BACKGROUND AND PURPOSE Dahl salt-sensitive rats fed an 8.7% NaCl diet exhibited hypertensive encephalopathy and developed seizures associated with areas of blood-brain barrier (BBB) disruption without brain ischemia. The incidence of hemorrhagic stroke was low (7/47). We tested the hypothesis that a defect in cerebral blood flow (CBF) autoregulation under… CONTINUE READING