Alterations in Vibrio cholerae motility phenotypes correlate with changes in virulence factor expression.

@article{Gardel1996AlterationsIV,
  title={Alterations in Vibrio cholerae motility phenotypes correlate with changes in virulence factor expression.},
  author={Claudette Gardel and John J Mekalanos},
  journal={Infection and immunity},
  year={1996},
  volume={64 6},
  pages={2246-55}
}
Motility is thought to contribute to the virulence of Vibrio cholerae, but the role it plays in pathogenesis is not completely understood. To investigate the influence of motility on virulence gene expression and intestinal colonization, we have isolated mutants with altered swarming abilities in soft agar medium. Both spontaneous hyperswarmer (exhibiting faster swarm rates) and spontaneous or transposon-induced nonmotile mutants of strain 0395 were obtained. Surprisingly, we found that two of… CONTINUE READING
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