Alterations in Phosphorylated CREB Expression in Different Brain Regions following Short- and Long-Term Morphine Exposure: Relationship to Food Intake

@inproceedings{Ren2013AlterationsIP,
  title={Alterations in Phosphorylated CREB Expression in Different Brain Regions following Short- and Long-Term Morphine Exposure: Relationship to Food Intake},
  author={Xiuhai Ren and Kabirullah Lutfy and Michael Mangubat and M{\'o}nica G. Ferrini and Martin Laurence Lee and Yanjun Liu and Theodore C Friedman},
  booktitle={Journal of obesity},
  year={2013}
}
BACKGROUND Activation of the cyclic adenosine monophosphate (cAMP)/phosphorylated CREB (P-CREB) system in different brain regions has been implicated in mediating opioid tolerance and dependence, while alteration of this system in the lateral hypothalamus (LH) has been suggested to have a role in food intake and body weight. METHODS Given that opioids regulate food intake, we measured P-CREB in different brain regions in mice exposed to morphine treatments designed to induce different degrees… CONTINUE READING
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