Alterations in NMDA Receptor Subunit Levels in the Brain Regions of Rats Chronically Administered Typical or Atypical Antipsychotic Drugs

@article{Hanaoka2003AlterationsIN,
  title={Alterations in NMDA Receptor Subunit Levels in the Brain Regions of Rats Chronically Administered Typical or Atypical Antipsychotic Drugs},
  author={Tadahito Hanaoka and Hirotaka Toyoda and Takafumi Mizuno and Hiroki Kikuyama and Kazushige Morimoto and Ryuichi Takahata and Hitoshi Matsumura and Hiroshi Yoneda},
  journal={Neurochemical Research},
  year={2003},
  volume={28},
  pages={919-924}
}
It has been hypothesized that glutamatergic neurotransmission is related to the therapeutic effect of antipsychotic drugs. To test this hypothesis, we measured by use of the Western blot technique the polypeptide levels of NMDA receptor subunits, that is, NMDAR1, 2A, 2B, and 2C, in several regions of the rat brain after chronic treatment with haloperidol (HPD) or clozapine (CLZ). Each rat was intraperitoneally injected with HPD or CLZ at 10:00 h daily for 14 days. The brain regions examined… CONTINUE READING