Alterations in NFk B function in transgenic epithelial tissue demonstrate a growth inhibitory role for NFk B

@inproceedings{Seitz1998AlterationsIN,
  title={Alterations in NFk B function in transgenic epithelial tissue demonstrate a growth inhibitory role for NFk B},
  author={Cornelia S. Seitz and Qun Di Lin and Helen Deng and Paul A. Khavari},
  year={1998}
}
Stratified epithelium contains a mitotically active basal layer of cells that cease proliferating, then migrate outwards and undergo terminal differentiation. The control of this process, which is abnormal in cutaneous neoplasia and inflammation, is not well understood. In normal epidermis, NF-kB proteins were found to exist in the cytoplasm of basal cells and then to localize in the nuclei of suprabasal cells, suggesting a role for NF-kB in the switch from proliferation to growth arrest and… CONTINUE READING

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